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Amoxypen (Amoxil)
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Amoxypen

Amoxypen is a penicillin-like (beta-lactam) antibiotic. It belongs to the most widely-used group of antibiotics available. Amoxypen is usually the drug of choice within the class because it is better absorbed, following oral administration, than other beta-lactam antibiotics.

Other names for this medication:
Amoksicilin, Amoxi, Amoxicilina, Amoxicillin, Amoxil, Cipmox, Clamoxyl, Flemoxin, Gimalxina, Lupimox, Novamoxin, Ospamox, Penamox, Polymox, Servamox, Velamox, Wymox, Zimox

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Also known as:  Amoxil.

Description

Amoxypen is one of the best forms of antibiotic available today. It is used to treat infections caused by certain bacteria, including: infections of the ear, nose, and throat (pneumonia, bronchitis); infections of the genitourinary tract; infections of the skin and skin structure; infections of the lower respiratory tract; gonorrhea, acute uncomplicated (ano-genital and urethral infections) in male and females.

Amoxypen is also used before some surgery or dental work to prevent infection. It is also used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers. Amoxypen may also be used for other purposes not listed here.

Amoxypen acts by inhibiting the synthesis of bacterial cell wall and stopping the growth of bacteria.

Amoxypen is available in capsules.

Amoxypen is usually taken every 8 hours (three times a day). It can be taken with or without food.

The chewable tablets should be crushed or chewed thoroughly before they are swallowed. The tablets and capsules should be swallowed whole and taken with a full glass of water.

Take Amoxypen exactly as directed. Do not take more or less Amoxypen or take it more often than prescribed by your doctor. Do not stop taking Amoxypen without talking to your doctor. To clear up your infection completely, continue taking Amoxypen for the full course of treatment even if you feel better in a few days. Stopping Amoxypen too soon may cause bacteria to become resistant to antibiotics.

Dosage

Children and Adolescents 2 years and older (standard-dose therapy): 45 mg/kg/day PO in divided doses every 12 hours is the standard dose for children with uncomplicated disease that is mild to moderate in severity who do not attend daycare and who have not been treated with an antimicrobial agent in the previous 4 weeks.

Children and Adolescents 2 years and older (high-dose therapy): 80 to 90 mg/kg/day PO in divided doses every 12 hours (Max: 2 g/dose) is recommended for children in areas with high rates of S. pneumoniae resistance (more than 10%, including intermediate- and high-level resistance).

Children younger than 2 years should be treated with Amoxypen; clavulanic acid, not Amoxypen alone.

Overdose

In case of overdosage, discontinue medication, treat symptomatically, and institute supportive measures as required. If the overdosage is very recent and there is no contraindication, an attempt at emesis or other means of removal of drug from the stomach may be performed. A prospective study of 51 pediatric patients at a poison-control center suggested that overdosages of less than 250 mg/kg of Amoxypen are not associated with significant clinical symptoms and do not require gastric emptying.

Interstitial nephritis resulting in oliguric renal failure has been reported in a small number of patients after overdosage with Amoxypen.

Crystalluria, in some cases leading to renal failure, has also been reported after Amoxypen overdosage in adult and pediatric patients. In case of overdosage, adequate fluid intake and diuresis should be maintained to reduce the risk of Amoxypen crystalluria.

Renal impairment appears to be reversible with cessation of drug administration. High blood levels may occur more readily in patients with impaired renal function because of decreased renal clearance of Amoxypen. Amoxypen may be removed from circulation by hemodialysis.

Storage

Store between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep bottle closed tightly. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Amoxypen are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur, Amoxypen should be discontinued and appropriate therapy instituted.

A high percentage of patients with mononucleosis who receive ampicillin develop an erythematous skin rash. Thus, ampicillin-class antibiotics should not be administered to patients with mononucleosis.

Prescribing Amoxypen in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

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To determine the Helicobacter pylori eradication rates using lansoprazole, amoxicillin and clarithromycin for seven days, in patients with peptic ulcer disease in a well developed urban area in Brazil.

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A significant number of inappropriate antibiotic prescriptions were issued for infections with a high probability of bacterial resistance to the prescribed antibiotics.

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Most urinary tract infections (UTI) are caused by Escherichia coli. Integrons have an important role in distributing antibiotic resistance genes among bacteria.

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Salmonella spp. isolates obtained from healthy swine in 2008 were analyzed for antibiotic resistance phenotypes and genotypes. The resistance profiles of the 2008 isolates were compared with those of a Salmonella collection isolated from the same geographical area in 2005. The 2008 isolates consisted of strains that were 97% oxytetracycline resistant, 33.3% amoxicillin resistant, 31.8% amoxicillin- plus clavulanic acid resistant, 27.5% trimethoprim-sulfamethoxazole resistant, 17.3% streptomycin resistant, and 7.2% enrofloxacin-ciprofloxacin resistant. The presence of integrons and resistance genes and their topological association in resistant strains was assessed by PCR. The prevalence of class 1 integrons was the highest, at 46.2%, while class 2 integrons were present in 17.9% of the isolates. In strains that harboured class 1 integrons, we identified 3 different gene cassette arrangements; a single class 2 integron arrangement of dfrA1-sat1-aadA1 was found. Comparison of these results with data obtained from the 2005 isolates showed that Salmonella strains resistant to amoxicillin and amoxicillin plus clavulanic acid had clearly emerged over the span of 3 years, along with an increase in the prevalence of class 1 integrons and the acquisition of new gene cassette arrangements. These findings highlight the need for continual monitoring of regional isolates to establish more efficient vigilance programs that can address variations in resistance over short periods of time within the same geographical area.

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Levofloxacin has been shown to be effective in Helicobacter pylori eradication. Two 10-day levofloxacin-based triple therapies were compared with standard 7- and 14-day quadruple regimens in second-line treatment.

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The prevalence of antimicrobial resistance was 0% versus 3.1% to AMO, 0% versus 2% to TET, 27% versus 41.3% to MET (p<0.05), 18% versus 45.8% to CLA (p<0.05) and 3% versus 14.6% to LEV (p<0.05) in Group 1 vs Group 2, respectively. In Group 2, there was an increased prevalence of H pylori strains resistant to multiple antimicrobials.

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We collected urine culture results from 0-18-year-old patients in the National Taiwan University Hospital from January 1, 2003 to October 31, 2012. Their medical chart was reviewed to identify true pathogens responsible for their urinary tract infection (UTI). We checked the percentage of susceptibility of these pathogens to ampicillin, amoxicillin-clavulanate (AMC), cefazolin, cefmetazole, ceftriaxone, gentamicin, and trimethoprim-sulfamethoxazole (TMP-SMX) according to the Clinical and Laboratory Standards Institute (CLSI) guideline. The extended-spectrum-beta-lactamases (ESBLs) rate was also checked. In addition, we reviewed the treatment response of different antibiotics. Defervescence within 48 hours after initial antibiotics use was considered responsive.

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Burkholderia pseudomallei is the etiologic agent of melioidosis. This multifaceted disease is difficult to treat, resulting in high morbidity and mortality. Treatment of B. pseudomallei infections is lengthy and necessitates an intensive phase (parenteral ceftazidime, amoxicillin-clavulanic acid or meropenem) and an eradication phase (oral trimethoprim-sulfamethoxazole). The main resistance mechanisms affecting these antibiotics include enzymatic inactivation, target deletion and efflux from the cell, and are mediated by chromosomally encoded genes. Overproduction and mutations in the class A PenA β-lactamase cause ceftazidime and amoxicillin-clavulanic acid resistance. Deletion of the penicillin binding protein 3 results in ceftazidime resistance. BpeEF-OprC efflux pump expression causes trimethoprim and trimethoprim-sulfamethoxazole resistance. Although resistance is still relatively rare, therapeutic efficacies may be compromised by resistance emergence due to increased use of antibiotics in endemic regions. Novel agents and therapeutic strategies are being tested and, in some instances, show promise as anti-B. pseudomallei infectives.

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Currently established first line therapy of acute (presumed bacterial) rhinosinusitis (ARS) consists of 10 to 14 days of oral amoxicillin or cephalosporins. This study compared the clinical efficacy and tolerance of cefcapene pivoxil (CP) and amoxicillin-clavulanate (AMC) in patients with ARS.

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In both groups, skin test reactivity tended to decrease, and although greater in Group A, the difference was not significant compared with Group B. Median RAST values also decreased over time and showed no differences in the exposed group compared with the controls. One patient in Group A became positive to benzylpenicilloyl (BPO), despite becoming negative to AX.

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This first pharmacogenomics study on the influence of different CYP genotypes on H. pylori therapy suggests that, as in Asian populations, CYP2C19 genotype patterns are probably also relevant in Caucasians receiving H. pylori eradication regimens that include omeprazole. The possibility of a favorable drug interaction mediated by CYP2C19 and CYP3A4 requires investigation.

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amoxypen 500 mg saft 2015-06-21

To investigate the relation Keflex Schedule Drug Classification between Helicobacter pylori infection and the clinical features of idiopathic thrombocytopenic purpura (ITP), and to examine the effects of H. pylori eradication on platelet counts.

amoxypen alcohol 2015-06-07

Esomeprazole 40 mg twice daily for triple therapy may improve Cepodem Tablet the H. pylori eradication compared to omeprazole-based therapy, but only for homologous extensive metabolizers of CYP2C19.

amoxypen 125 mg 2016-09-08

The results showed that the amount of bacteria present in the fluid was significantly higher than the amount isolated Metronidazole Breastfeeding after antibiotic treatment. Also, most of the microorganisms present in the fluid collected before antibiotic administration were strict anaerobes.

amoxypen tabs 2017-12-10

The presence of beta-lactamase-producing bacteria is associated with the failure of penicillins to eradicate Group A beta-hemolytic streptococci in patients with pharyngo-tonsillitis. This study correlated the rate of recovery of beta-lactamase-producing bacteria from healthy children with the rate of amoxicillin failure to eradicate Group A streptococci from children with acute Ciprofloxacin Mixed With Alcohol Group A streptococcal pharyngo-tonsillitis.

amoxypen 750 mg dosierung 2015-03-04

Fifty-five infants exposed to macrolide antibiotics were compared to a control cohort of 36 infants exposed to amoxicillin via lactation. The infants in the macrolide group were all exposed to erythromycin and the newer macrolides: azithromycin, clarithromycin, and roxithromycin. The rate of adverse reactions the infant experienced while being exposed to both antibiotics was comparable. Seven (12.7%) infants in the macrolide group experienced adverse reactions versus three infants ( Amocla 625 Mg Antibiotic 8.3%) in the amoxicillin group (odds ratio = 1.6, 95% confidence interval, 0.38-6.65, p = 0.73). The adverse reactions in the infants exposed to macrolides were rash, diarrhea, loss of appetite, and somnolence, whereas the infants exposed to amoxicillin experienced rashes and somnolence. Factors such as gestational age, age and weight at exposure, maternal age, or type of macrolide were not associated with the infant's adverse reaction in multivariate regression analysis.

amoxypen 250 mg saft 2015-09-14

Cost-effectiveness analysis of RSA and RSC treatment from an institutional perspective. Effectiveness outcome was defined as the percentage of cure. A decision tree with a Bayesian approach included the following therapeutic alternatives: ciprofloxacin, Klavunat Bid 1000 Mg Shqip gatifloxacin, trimetoprim/sulfametoxazol (TMP/SMX), amoxicilin/clavulanic acid (AAC) and clindamicin.

amoxypen en alcohol 2016-07-09

Two thousand nine hundred and forty-three adults submitted urine samples. Susceptibility among E. coli isolates and antibiotic prescribing data were available from 618 patients. We found no evidence of an association between resistance and patients' exposure to any antibiotic prescribed in primary care in the previous 12 months [adjusted odds ratio (OR) 1. Azithromycin Where To Buy 12, 95% confidence interval 0.77-1.65, P = 0.52]. Secondary analyses demonstrated greater resistance in patients exposed to antibiotics within 2 months (adjusted OR 1.95, 1.08-3.49, P = 0.03), a dose-response relationship to increasing exposure to trimethoprim in the previous 12 months (adjusted OR 1.01, 1.01-1.02, P = 0.001) and that individuals who had been prescribed any beta-lactam antibiotic in the previous 12 months had amoxicillin MICs more than twice (adjusted 95% CI 1.23-3.31, P = 0.009) that of those who had not been prescribed any beta-lactams.

amoxypen tablets 2017-11-27

Patients with blaKPC-positive K. pneumoniae infection, were prospectively screened and were categorised Dalacin Y Alcohol into two groups: patients in the study group received a combination-based therapy of cefepime and amoxicillin/clavulanic acid and the control group received tigecycline-based therapy. The pathogen clearance rate, 28-day mortality and cost of the antibiotic treatment were compared between the two groups. Moreover, the checkerboard microdilution method was performed to determine the synergy between cefepime and amoxicillin/clavulanic acid in vitro.

amoxypen 750 mg 2015-01-17

High-dose PPI-amoxicillin dual therapy is comparable to recommended rescue therapies for H. pylori infection. More researches are needed to determine the efficacy of high-dose dual therapy as a first-line therapy.

amoxypen 1000 mg 2015-02-11

We report a case of melioidosis with splenic abscesses caused by Burkholderia pseudomallei in an urban-dwelling, 54-year-old Taiwanese man. The patient presented with prolonged fever and abdominal pain. A splenectomy was performed, followed by successful treatment with ceftazidime and amoxicillin-clavulanate. The patient recovered fully.

amoxypen 500 mg saft 2017-10-21

Empirical antibiotic treatment of lower urinary tract infections should be based on the patient's clinical data and on local sensitivity data. Because of the increase in resistance among uropathogens, recommendations on the empirical treatment of urinary tract infections have been modified. Currently, the empirical use of co-trimoxazole, ampicillin, and first-generation cephalosporins and quinolones is not recommended. Fluoroquinolones have been demonstrated to be highly effective in comparative studies but, because of the increase in resistance, the type of patient who can benefit from these antimicrobial agents must be selected. Second- and third-generation cephalosporins still have high sensitivity rates, although the higher recurrence rates associated with their use and the emergence of extended-spectrum beta-lactamase-producing enterobacterial in the community should be taken into account. Amoxicillin-clavulanate is less effective in eradicating infections than quinolones. Fosfomycin-trometamol has resistance rates of below 2% and single-dose therapy has been demonstrated to be safe and effective. Nitrofurantoin is also currently active, although it must be administered for 7 days and can produce toxicity. Both agents are currently recommended as alternative therapeutic options to fluoroquinolones in uncomplicated infections of the lower urinary tract.

amoxypen alcohol 2016-04-07

Nonadherence in prescribing first-choice antibiotics to patients with tonsillitis or pharyngotonsillitis is highly prevalent. We emphasize the need to implement measures to help minimize this problem and, thus, antibiotic resistance, such as undertaking qualitative studies to assess the reasons for inappropriate prescription or the incorporation of alert systems in the electronic records.