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Binozyt (Zithromax)

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Binozyt is a macrolide antibiotic of azalides group. Binozyt inhibits RNA-dependent protein synthesis of sensitive microorganisms. It active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes group A); gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila; anaerobic bacteria: Bacteroides fragilis.

Other names for this medication:
Azatril, Azenil, Azibiot, Azicip, Azifast, Azigram, Azilide, Azimac, Azimax, Azimed, Azinix, Azithral, Azithromycin, Azitro, Azitrobac, Azitrocin, Azitrom, Azitromicina, Azitrox, Aziwok, Azomax, Aztrin, Azycyna, Azyth, Hemomycin, Koptin, Macrozit, Mezatrin, Misultina, Ricilina, Sumamed, Tritab, Tromix, Trozocina, Zertalin, Zibramax, Zimax, Zistic, Zithrin, Zithrogen, Zithromax, Zithrox, Zitrocin, Zival, Zocin, Zomax, Zycin

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Biaxin, Chloromycetin, Cipro, Tetracycline, Omnicef

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Also known as:  Zithromax.


Binozyt is used to treat certain bacterial infections in many different parts of the body. This medicine may mask or delay the symptoms of syphilis. It is not effective against syphilis infections.

Binozyt belongs to the class of drugs known as macrolide antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Powder for Suspension, Tablet, Powder for Suspension, Extended Release, Capsule.


Generic Binozyt is available in: 250 mg (Low Dosage), 500 mg (Standard Dosage).

Generic Binozyt can be taken in tablets, liquid form, injections. You should take it by mouth with water.

To avoid problems with stomach, take tablets and liquid form with meals. Liquid Generic Binozyt form should be shook properly. Capsule is taken on empty stomach.

It is better to take Generic Binozyt every day at the same time.

Generic Binozyt treats different types of bacterial infections and can be used both by adults and by children. Thus, each age has different instructions.

For children it is better to take into account child weight. In treatment of otitis media, take Generic Binozyt for 1-5 days.

For Adults: if you treat Pneumonia or Throat/Tonsil Infection the right dose is two tablets of 250 mg on the first day and then 250 mg once a day for 4 more days.

In prevention of MAC (mycobacterium avium complex) usual Generic Binozyt dosage is 1,200 mg for a week.

In treatment of skin or infections usual Generic Binozyt dosage is two tablets of 250 mg at the first day after you took one tablet of 250 mg for 4 days at the same time.


If you overdose Binozyt and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Binozyt overdosage: discomfort feeling in stomach, diarrhea, retching, nausea.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Binozyt are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take antacids that contain aluminum or magnesium within 2 hours of taking Binozyt.

Before taking Binozyt, tell your doctor if you are using any of the following drugs: nelfinavir (Viracept); digoxin (Lanoxin, Lanoxicaps); ergot medicine such as methysergide (Sansert), ergotamine (Ergostat, Medihaler, Cafergot, Ercaf, Wigraine), dihydroergotamine mesylate (D.H.E., Migranal Nasal Spray); triazolam (Halcion); carbamazepine (Carbatrol, Tegretol); cyclosporine (Neoral, Sandimmune); phenytoin (Dilantin); cholesterol-lowering medicines such as lovastatin (Mevacor), atorvastatin (Lipitor), or cerivastatin (Baycol); a calcium channel blocker such as diltiazem (Cartia XT, Diltiazem, Tiazac), felodipine (Plendil), nicardipine (Cardene), nifedipine (Procardia, Adalat), nimodipine (Nimotop), verapamil (Calan, Covera-HS); HIV medicines such as indinavir (Crixivan), ritonavir (Norvir), saquinavir (Invirase); alprazolam (Xanax), diazepam (Valium), midazolam (Versed), triazolam (Halcion); theophylline (Theo-Dur, Theolair, Theochron); warfarin (Coumadin); pimozide (Orap); or another antibiotic, especially clarithromycin (Biaxin) or erythromycin (E-Mycin, E.E.S, Ery-Tab).

If you are using any of these drugs, you may not be able to use Binozyt, or you may need dosage adjustments or special tests during treatment.

There are many other medicines that can interact with Binozyt. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors.

Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

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We present the case of a 75-year-old woman with a history of fibromyalgia who was admitted with mild limb weakness and lower abdominal purpura. She was prescribed pregabalin (75mg, twice daily) for almost 3 months to treat chronic back pain. Her medical history revealed that 3days before admission, she began experiencing acute bronchitis and was treated with a single dose of azithromycin (500mg). She had developed rapid onset severe myalgia, mild whole body edema, muscle weakness leading to gait instability, abdominal purpura and tender purpura on the lower extremities. Laboratory values included a white blood cell count of 25,400/mL and a creatinine phosphokinase (CPK) concentration of 1250 IU/L. Based on these findings and the patient's clinical history, a diagnosis of pregabalin- and azithromycin-induced rhabdomyolysis was made.

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Distinguishing between treatment failure and re-infection is important in order to refine treatment recommendations and focus infection control mechanisms. If a large proportion of repeat chlamydia infections are due to antibiotic treatment failure, then international recommendations on chlamydia treatment may need to be re-evaluated. If most are re-infections, then strategies to expedite partner treatment are necessary.

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PIVA and PIMA showed properties in almost complete contrast with those of chloroquine and azithromycin, i.e., fast apparent accumulation and fast release at 4 degrees C as well as at 37 degrees C, saturation of uptake (apparent Kd 40 microM), no influence of monensin, MRP, or P-gp inhibitors; tight binding to liposomes (Kd approx. 40 microM); and sharp increase in calculated free energy when forced in the hydrophobic domain.

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Nucleic acid amplification tests are now considered the method of choice to detect Chlamydia trachomatis. These assays have highest sensitivity and also high specificity, comparable to culture. First-void urine is the preferred specimen for urogenital infections of males, whereas vaginal and cervical swabs are at least as effective for testing female lower genital tract infections. Chlamydia point-of-care tests may produce results rapidly without special equipment but lack diagnostic accuracy and thus are unsuitable for routine use. Serology is not useful for detection of acute infections, but may help to identify persistent infections with Chlamydia no longer detectable in swabs or urine specimens. Various guidelines recommend doxycycline and azithromycin for treatment of uncomplicated Chlamydia infection. Alternatively erythromycin, ofloxacin and levofloxacin can be used. Persistent infections usually require treatment for longer periods or by using combinations of different antibiotics.

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The analysis of the published experimental and clinical data on chemoprophylaxis and chemotherapy of rickettsiosis and Q fever confirmed the preserved role of doxycycline, the main drug of choice in the treatment of the diseases, then followed chloramphenicol. Macrolides, such as azithromycin and clarithromycin proved to be useful in pediatric practice and the treatment of pregnant women with rickettsiosis. The treatment of acute and chronic Q fever required the use of doxycycline, fluoroquinolobes, co-trimoxazole and hydroxachloroquine in combined therapy. It is concluded that in vivo studies of novel drugs and investigation of prospective macrolides and fluoroquinolones are necessary. Clinical trials of a new glycycline, i.e. tigecycline, which experimentally showed highy strong activity against the Q fever pathogen, should be accelerated.

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C. jejuni as well as some hippurate-negative Campylobacter species and related diarrheagenic organisms, are the leading cause of gastroenteritis in our environment all throughout the year. The aim of the present study was to determine the sensitivity of hippurate-negative Campylobacter and Helicobacter pullorum strains isolated from the stools of patients with diarrhea. We tested 39 Campylobacter coli, two C. lari and five Helicobacter pullorum strains identified by mass spectrometry analysis. The sensitivity to amoxicillin-clavulanic acid, erytrhomycin, azithromycin, gentamicin, ciprofloxacin, levofloxacin, tetracycline, tigecycline and chloramphenicol was tested by E-test. Most hippurate-negative Campylobacter and H. pullorum isolates studied showed high resistance to tetracycline and to the two fluorquinolones tested. On the other side, all strains were sensitive to amoxicillin-clavulanic acid, tigecycline and chloramphenicol, while most of them were sensitive to both macrolides tested and to gentamicin.

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Resistance was common to sulphonamides and co-trimoxazole, however >or=95% meningococci tested were susceptible to drugs commonly used in the treatment of meningococcal disease, including penicillin and ceftriaxone. Relative insusceptibility to rifampicin was more common but did not increase during the 29-year period. For all drugs tested, except rifampicin, there was good agreement between agar dilution and E test results.

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Rabbits were treated with either a single administration of 1% azithromycin solution with or without polycarbophil, or with multiple administrations of 1% azithromycin solution in polycarbophil. Drug concentrations were measured using LC/MS/MS. Conjunctiva, cornea, aqueous humor, and tear samples were analyzed over a period of 144 h after a single administration of azithromycin with or without polycarbophil. Eyelid, conjunctiva, cornea, aqueous humor, and tear samples were collected over a period of 288 h during and after multiple administrations of azithromycin.

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Four macrolides-6-O-methyl-8a-aza-8a-homoerythromycin, clarithromycin, azithromycin and azithromycin 11,12-cyclic carbonate, have been selected for the construction of a series of new quinolone derivatives. The quinolone moiety is connected to the macrolide scaffold via a diaminoaklyl 4''-O-propionyl ester chain of varying length. At the terminus the linker is attached via one of the nitrogen atoms in the linker at C(6) or C(7) of the quinolone. Many of compounds described, particularly clarithromycin derivative 37, and azithromycin derivatives 48 and 55, exhibited excellent antibacterial activity against a wide range of clinically relevant macrolide-resistant organisms, with profiles superior to that of telithromycin, an enhanced spectrum ketolide.

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binozyt 500 mg harga 2017-02-09

Human babesiosis has been documented in many countries. It is a zoonotic protozoan disease of medical, veterinary and economic importance. In this study, a twelve years old boy was referred to the hospital with intermittent fever of unknown origin. On clinical, parasitological and serological bases Hostacycline Tablet the case proved to be babesiosis. The boy acquired the infection from his pet dog which was heavily infested with Rhipicephalus sanguineus and suffered a mild feature of animal babesiosis. The patient was successfully treated with Atovaquone plus Azithromycin without relapse for one month follow up. The pet dog was sent to Governmental Veterinary Hospital at Abbassia for treatment from babesiosis and tick infestation.

binozyt 500mg tablets uses 2015-09-14

RSV is the most significant cause of serious lower respiratory tract infection in infants and young children worldwide. There is currently no vaccine for the virus, and antiviral therapy (e.g., ribavirin) has shown no efficacy against the disease. We reported that alternatively activated macrophages (AAMs) mediate resolution of RSV-induced pathology. AAM differentiation requires macrophage-derived IL-4 and -13, autocrine/paracrine signaling through the type I IL-4 receptor, and STAT6 activation. Based on these findings, we reasoned that it would be possible to intervene therapeutically in RSV disease by increasing AAM differentiation, thereby decreasing lung pathology. Mice treated with the IL-4/anti-IL-4 immune complexes, shown previously to sustain levels of Orelox Generic circulating IL-4, increased the RSV-induced AAM markers arginase-1 and mannose receptor and decreased the lung pathology. Induction of PPARγ, shown to play a role in AAM development, by the PPARγ agonist rosiglitazone or treatment of mice with the macrolide antibiotic AZM, also reported to skew macrophage differentiation to an AAM phenotype, increased the AAM markers and mitigated RSV-induced lung pathology. Collectively, our data suggest that therapeutic manipulation of macrophage differentiation to enhance the AAM phenotype is a viable approach for ameliorating RSV-induced disease.

que es binozyt 500 mg 2017-12-26

AMCNS-S (or AMCNS-L) had high bioavailability Cefdinir Suspension , for example, the oral (or intravenous) relative bioavailability of AMCNS-S (or AMCNS-L) to free AM increased to 273.19% (or 163.50%). After intravenous administration, AMCNS-S (or AMCNS-L) had obvious lung targeting efficiency, for example, the lung AM concentration of AMCNS-S (or AMCNS-L) increased 16 (or 28) times that of free AM at 12 h; the AM concentration of AMCNS-S (or AMCNS-L) in lung was higher than that in heart and kidney all the time.

binozyt dosage 2016-06-05

In the 1980s, the major pathogen isolated Cefdinir 125 5 Suspension was Mycobacterium abscessus. In the 1990 s, Mycobacterium chelonae emerged as the major pathogen. By 2000, it was responsible for more than 50% of all cases. The majority of M. abscessus and Mycobacterium fortuitum were from southern coastal states and Texas, whereas M. chelonae isolates were more widespread geographically. The most active antimicrobials were amikacin and clarithromycin/azithromycin for M. abscessus and clarithromycin/azithromycin, amikacin, and tobramycin, and the quinolones for M. chelonae.

binozyt capsules 2016-03-22

The odds ratios for pelvic inflammatory disease Amoxil 500 Mg Tablets associated with use of prophylactic doxycycline or azithromycin compared with placebo or no treatment was 0.89 (95%CI 0.53-1.51). Use of prophylaxis was associated with a small reduction in unscheduled vists to the provider (OR 0.82; 95% CI 0.70-0.98). Use of doxycycline or azithromycin had little effect on the likelihood of removal of the IUD within 90 days of insertion (OR 1.05; 95% CI 0.68-1.63). Significant heterogeneity did not exist between studies.

binozyt 250 mg dosage 2016-08-20

Our results indicate azithromycin is a potential Sumamed Tablets therapeutic option for enteric fever. Standardized laboratory testing methods and interpretation for azithromycin against Salmonella enterica would allow laboratories to report upon this antibiotic with confidence.

binozyt penicillin 2016-02-09

To determine the efficacy of a short course of antibiotics (<4 days) in comparison to a Cepodem 100 Suspension longer course (>4 days) for the treatment of acute otitis media in children.

binozyt 500 mg 2016-12-13

Whooping cough is a highly contagious disease. Proxime 750 Mg Para Que Sirve Infants are at highest risk of severe disease and death. Erythromycin for 14 days is currently recommended for treatment and contact prophylaxis, but is of uncertain benefit.

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A hypothetical cohort of 5000 women followed over 10 years Amoxicillin 500 Mg 2 Capsules Twice A Day .

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A single dose of azithromycin has been shown to reduce severe post-surgical trichiasis recurrence rates Zindaclin 1 Gel Clindamycin Phosphate to one year and should become standard post surgical treatment.

binozyt 250mg capsule 2015-12-31

The purpose of the present study is to establish a new animal model of azithromycin (AZ)-induced liver injury and study the molecular pathological change during the process. First, mice were respectively injected intraperitoneally with AZ of different high doses. Our results showed that 800 mg/kg AZ injection significantly induced liver injury in the mice, which reflected an ideal process of liver injury and repair. In this study, we analyzed the molecular pathological changes during the process by hematoxylin and eosin staining, immunohistochemistry, Western blot, and quantitative real-time reverse transcription polymerase chain reaction in the liver of mice at 0, 12, 24, 48, and 72 h after 800 mg/kg injection. Our results showed that the expression of heat shock protein 70, proliferating cell nuclear antigen, vascular endothelial growth factor, caspase 3, and cytochrome P450 2E1 were significantly differently expressed during liver injury induced by 800 mg/kg AZ in mice. Our results will be conducive for further study of the pathogenesis and prevention of drug-induced liver injury.