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Dalacin

Dalacin is used for treating serious infections caused by certain bacteria. Dalacin is a lincomycin antibiotic. Dalacin kills sensitive bacteria by stopping the production of essential proteins needed by the bacteria to survive.

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Antirobe, Basocin, Biodaclin, Chloramphenicol, Clendix, Cleocin, Clidan, Climadan, Clinacin, Clinda, Clindacin, Clindacne, Clindagel, Clindahexal, Clindal, Clindamax, Clindamicina, Clindasol, Clindesse, Clindets, Clinium, Clinsol, Clinwas, Cutaclin, Dentomycin, Derma, Dermabel, Evoclin, Klimicin, Klindamicin, Klindan, Mediklin, Sobelin, Tidact, Ziana, Zindaclin

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Clinda derm, Clindagel, Clindets

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Also known as:  Cleocin.

Description

Dalacin is a prescription medication used to treat bacterial infections of the lungs, skin, blood, bones, joints, female reproductive system, and internal organs.

Dalacin belongs to a group of drugs called lincomycin antibiotics. These work by stopping the growth of bacteria.

This medication is available as a vaginal cream, vaginal suppository, oral capsule, and oral liquid.

This medication is also available in injectable forms to be given directly into a vein (IV) or a muscle (IM) by a healthcare professional.

Common side effects of Dalacin include nausea, vomiting, joint pain, heartburn, pain when swallowing, and white patches in the mouth.

Dosage

Take Dalacin exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Take the capsule with a full glass of water to keep it from irritating your throat.

Measure the oral liquid with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Dalacin is sometimes given as an injection into a muscle, or injected into a vein through an IV. You may be shown how to use injections at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Use a disposable needle only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

To make sure this medicine is not causing harmful effects, you may need frequent medical tests during treatment.

If you need surgery, tell the surgeon ahead of time that you are using Dalacin.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Dalacin will not treat a viral infection such as the flu or a common cold.

Store at room temperature away from moisture and heat. Protect the injectable medicine from high heat.

Do not store the oral liquid in the refrigerator. Throw away any unused oral liquid after 2 weeks.

Overdose

In the event the patient misses a dose of Dalacin, the patient should take it as soon as possible. However, if it is almost time for the next scheduled dose, taking another dose of Dalacin may cause an overdose which can lead to serious health complications. In this case, the missed dose should be skipped entirely to avoid an overdose potential. If an overdose of Dalacin is suspected the patient should seek immediate medical intervention and assessment. An overdose may involve symptoms such as changes in mood or behaviors, thoughts of self harm, suicidal thoughts, seizures, or convulsions.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Dalacin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use Generic Dalacin if you are allergic to Generic Dalacin components or to to tartrazine.

Be very careful if you're pregnant or you plan to have a baby, or you are a nursing mother.

Try to be very careful with Generic Dalacin if it is given to children younger than 10 years old who have diarrhea or an infection of the stomach or bowel. Elderly patient should use Generic Dalacin with caution.

Be sure to use Generic Dalacin for the full course of treatment.

Avoid alcohol.

It can be dangerous to stop Generic Dalacin taking suddenly.

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Systemic antibiotics do not consistently eradicate GNB from the airway of mechanically ventilated newborns, therefore its empirical use for prophylaxis or treatment of airway colonization should be discouraged.

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This hospital based cross sectional study was done on 80 confirmed cases of falciparum malaria (either by peripheral smear or rapid diagnostic test) more than 12 years of age admitted in NKPSIMS and LMH from December 2009 to December 2010.A case sheet proforma was prepared and data (demographic profile, clinical feature, investigation, treatment, and complication) from all indoor patients was collected and analyzed.

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Penicillin-like drugs are found to be unstable in SCHAEDLER'S broth in forzen storage (--20 degrees C). Chloramphenicol, clindamycin and tetracycline remained at original potency to 45 days. No detectable antimicrobial decay was found in two formulations of supplemented BHI broth. Antimicrobial potency was measured by quality control organism endpoints, bioassays and MIC changes in use at four clinical microbiology laboratories.

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The antimicrobial susceptibility of 1,117 clinical isolates of anaerobic bacteria was determined by the agar dilution technique. Metronidazole was the most active agent; only Propionibacterium acnes and Actinomyces sp. isolates were resistant. Clindamycin and chloramphenical were the next most effective agents. Beta-lactam antibiotics, with the exception of penicillin, were active against most anaerobes other than the Bacteroides fragilis group. At a breakpoint of 8 mg/l, 25% of Fusobacterium spp. and 30% of the non-fragilis Bacteroides spp. were resistant to penicillin. The highest resistance to beta-lactams was seen in the B. fragilis group. Within the indole-positive members of the group, resistance rates of 71% were seen for cefoxitin, 49% for moxalactam, 79% for cefotaxime, 22% for piperacillin and 89% for penicillin. We conclude that metronidazole has the most predictable in vitro activity against common clinical anaerobic isolates and that resistance to beta-lactams was frequent and of potential clinical importance as these latter agents are frequently used in the prophylaxis and therapy of mixed anaerobic infections.

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A recently described mycoplasma, Mycoplasma alligatoris, was isolated from dead American alligators (Alligator mississippiensis) that had demonstrated clinical signs of lethargy, anorexia, bilateral ocular discharge, edema. paraparesis, and polyarthritis. The in vitro minimum inhibitory concentration for nine antibacterial agents was determined through serial dilution in broth and plate culture for M. alligatoris isolates. The inhibitory concentration obtained for doxycycline, enrofloxacin, sarafloxacin, oxytetracycline, tilmicosin, and tylosin (< 1 microg/ml) was lower than that of clindamycin (1-8 microg/ml), chloramphenicol (8-16 microg/ml), and erythromycin (32-138 microg/ml).

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Sixty strains were identified as Enterococcus faecalis and one as Enterococcus faecium. All the virulence genes were detected in more than 93.3% (efa A and esp) of the E. faecalis strains, while the presence of phenotypic characteristics was much lower (gelatinase 10% and hemolysin 16.7%). Forty-six strains produced bacteriocins and one to six plasmids were detected in half of the isolates.

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Methicillin-resistant Staphylococcus aureus (MRSA) are commonly associated with nosocomial infections and are usually resistant to many antibiotics. This study describes the prevalence of MRSA strains and their antibiogram in a tertiary care hospital in Central India. The detection of MRSA was done by a cefoxitin (30 microg) disc diffusion test. Antibiotic sensitivity tests were done as per the Clinical and Laboratory Standards Institute guidelines 2006. Of the 280 S. aureus strains studied: 145 (51.8%) strains were MRSA; 51 (35.2%) MRSA strains were inducible clindamycin resistant; and all (100%) MRSA strains were resistant to penicillin and sensitive to vancomycin and linezolid. In order to detect the MRSA strains, cefoxitin disc diffusion tests should be used routinely in any microbiology laboratory to enable prompt treatment for the patient.

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Effects of altered plasma alpha-1-acid glycoprotein (AGP) levels on pharmacokinetic parameters of basic antimicrobials, erythromycin (EM), lincomycin (LM) and clindamycin (CM) were evaluated in pigs by simulation analysis. Intravenous (i.v.) injections of EM, LM and CM were performed to obtain pharmacokinetic parameters in healthy conditions. Binding parameters were obtained from an in vitro study using ultrafiltration. Simulation studies indicated that an increase of plasma AGP levels resulted in a decrease of both volume of distribution at steady state (Vdss) and total body clearance (Cltot) for all the drugs. Elimination rate constant for LM was almost unchanged by an increase of plasma AGP levels, whereas those for EM and CM were increased. Plasma concentration-time profiles at a high AGP level (often observed in pathophysiological conditions) were also simulated. All of the total plasma concentration-time profiles were different from those at normal AGP level. The differences were characterized by a higher initial concentration with faster or similar elimination. Unbound plasma concentration-time profile of LM was unaffected by AGP levels, whereas EM and CM were eliminated from plasma more rapidly at high AGP level. These results suggested that adjustment of dosage regimen of EM and CM is required in pathophysiological conditions, but that of LM is not required.

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To compare the effectiveness and safety of clindamycin/aminoglycoside with broad-spectrum beta-lactam monotherapy in Stomorgyl 2 Dosage patients with intra-abdominal infections by performing a meta-analysis of randomized controlled trials (RCTs).

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To investigate the serotypes, antibiotic susceptibilities, and multi-locus sequence type (MLST) profiles of Streptococcus agalactiae (S. agalactiae) in Beijing to provide Ofloxacin Eye Drops Cost references for the prevention and treatment of S. agalactiae infections.

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One hundred patients were treated for postpartum endometritis with ampicillin and clindamycin. Fifty Moxacil Capsule patients were analyzed retrospectively and 50 prospectively for therapeutic response and development of late infectious sequelae. Seventy-eight patients exhibited an acceptable clinical response. One patient developed a wound infection from Staphylococcus aureus, which responded to drainage. The remaining 21 patients responded to the addition of an aminoglycoside. No patient developed a pelvic abscess or septic thrombophlebitis. The therapeutic response of the 2 groups treated with ampicillin and clindamycin is contrasted with the results derived from the traditional antibiotic regimen of a penicillin and an aminoglycoside.

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Overall moxifloxacin MIC(50) and MIC(90) were 2 and 32 mg/L, respectively. Based on the current CLSI breakpoints (susceptible, < or =2 mg/L; resistant, > or =8 mg/L), almost half of the total isolates (49%) were non-susceptible to moxifloxacin (32% resistant; 17% intermediate). This was more evident among the non-fragilis Bacteroides species, where 47% of the isolates were resistant and 14% intermediate to moxifloxacin. Species variation was noticed, with the highest non-susceptible rates detected among Prevotella oralis (90%), Prevotella bivia ( Novidat Tablets 80%), Bacteroides thetaiotaomicron (75%), Bacteroides uniformis (70%) and Bacteroides capillosus (67%) species. Among the 19 (4%) isolates that were metronidazole non-susceptible (MIC > or = 16 mg/L), only 4 (21%) were additionally non-susceptible to moxifloxacin.

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Antibiotic regimens that contain aminoglycosides are not bioequivalent to those without aminoglycosides when effectiveness and adverse effects Denvar 400 Mg Precio are considered simultaneously. Antibiotic regimens that do not use aminoglycosides must be the first line of treatment for abdominal sepsis acquired in the community.

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Staphylococcus lugdunensis has emerged as a significant human pathogen, with distinct clinical and microbiological characteristics. Our goal was to identify the virulence factors in S. lugdunensis recovered from infected patients of two Greek hospitals during a six-year period (2008-2013). A collection of 38 S. lugdunensis was tested for biofilm formation, antimicrobial susceptibility, clonal distribution, virulence factors (ica operon, fbl, atlL, vwbl, slush) and antibiotic resistance genes (mecA, ermC) carriage. Strains were classified into pulsotypes by pulsed-field gel electrophoresis (PFGE) of SmaI DNA digests. The majority (22) was isolated from skin and soft tissue infections (SSTIs), nine from deep-sited infections (DSIs), including three bacteraemias and seven from prosthetic device-associated infections (PDAIs). All isolates were oxacillin-susceptible, mecA-negative and fbl-positive. Tab Amoxiclav Dose The highest resistance rate was detected for ampicillin (50%), followed by erythromycin and clindamycin (18.4%). Fourteen isolates (36.8%) produced biofilm, whereas 26/38 (68.4%) carried the ica operon. Biofilm formation was more frequent in isolates from PDAIs. Thirty-six strains (94.7%) carried atlL and 31 (81.6%) carried vwbl, whereas slush was detected in 15 (39.5%). PFGE revealed a low level of genetic diversity: strains were classified into seven pulsotypes, with two major clones (C: 22 and D: nine strains). Type C strains recovered from all infection sites prevailed in biofilm formation and ermC carriage, whereas type D strains associated with SSTIs and DSIs carried more frequently vwbl, slush or both genes. Despite susceptibility to antimicrobials, the clonal expansion and carriage of virulence factors, combined with biofilm-producing ability, render this species an important pathogen that should not be ignored.

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The Viriato Study is a nationwide, prospective, multicenter surveillance study of the antimicrobial susceptibility of bacterial pathogens commonly associated with community-acquired respiratory tract infections in Portugal. In 2003 and 2004 a Amoxil Dose total of 2945 isolates was recovered in the 29 laboratories that participated in the study. Testing was undertaken in a central laboratory. Of the 513 Streptococcus pyogenes strains isolated from patients with acute tonsillitis all were susceptible to penicillin and other beta-lactams but 18.9% were resistant to erythromycin, clarithromycin and azithromycin. The M phenotype dominated (67%), conferring resistance to erythromycin (MIC90 = 16 mg/L), clarythromycin and azithromycin, but susceptibility to clindamycin (MIC90 = 0.094 mg/L). From patients with lower respiratory tract infection 1,300 strains of Streptococcus pneumoniae, 829 of Haemophilus influenzae, and 303 of Moraxella catarrhalis were studied. Among S. pneumoniae isolates 18.4% were resistant to penicillin (3.5% showing high-level resistance), 7.1% to cefuroxime, 0.5% to amoxicillin and amoxicillin/clavulanate, 18.8% to erythromycin, clarithromycin and azithromycin, 14.9% to tetracycline, 16.5% to co-trimoxazole, and 0.4% to levofloxacin. Beta-lactamases were produced by 10.0% of H. influenzae and 96.4% of M. catarrhalis. In H. influenzae resistance to clarithromycin was 5.5% and to co-trimoxazole was 13.4%. Most strains were susceptible to amoxicillin/clavulanate, cefuroxime, azithromycin, tetracycline and ciprofloxacin. In M. catarrhalis resistance to co-trimoxazole was 27.1% and to tetracycline 1.0%. All strains were susceptible to amoxicillin/clavulanate, cefuroxime, clarithromycin, azithromycin and ciprofloxacin. Penicillin was the most active antimicrobial agent against S. pyogenes and amoxycillin/clavulanate and the quinolones the most active in vitro simultaneously against S. pneumoniae, H. influenza and M. catarrhalis.

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Use of human epidermal growth factor receptor inhibitors by oncologists has led to the occurrence of an acne-like eruption that is technically a folliculitis. Misidentification of the rash often leads to unfruitful treatment attempts as its morphologic features do not correlate well with its histologic findings. We describe a case history, diagnosis, and management of a man undergoing treatment with cetuximab for colorectal carcinoma who experienced the characteristic follicular eruption. Our patient responded well to daily moisturizers and 1% clindamycin gel and experienced near complete resolution of the rash. The evolving research and understanding of this unique entity are also discussed.

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Twelve city hospitals in The Netherlands.