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Klindan (Cleocin)
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Klindan

Klindan (generic name: clindamycin; brand names include: Clindatec / Dalacin / Clinacin / Evoclin) is used to treat a wide variety of serious bacterial infections including infections of the respiratory tract, skin and soft tissue, pelvis, vagina, and abdomen. It is also used to treat bone and joint infections, particularly those caused by Staphylococcus aureus. Klindan kills sensitive bacteria by stopping the production of essential proteins needed by the bacteria to survive.

Other names for this medication:
Antirobe, Basocin, Biodaclin, Chloramphenicol, Clendix, Cleocin, Clidan, Climadan, Clinacin, Clinda, Clindacin, Clindacne, Clindagel, Clindahexal, Clindal, Clindamax, Clindamicina, Clindasol, Clindesse, Clindets, Clinium, Clinsol, Clinwas, Cutaclin, Dalacin, Dentomycin, Derma, Dermabel, Evoclin, Klimicin, Klindamicin, Mediklin, Sobelin, Tidact, Ziana, Zindaclin

Similar Products:
Clinda derm, Clindagel, Clindets

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Also known as:  Cleocin.

Description

Klindan is a prescription medication used to treat bacterial infections of the lungs, skin, blood, bones, joints, female reproductive system, and internal organs.

Klindan belongs to a group of drugs called lincomycin antibiotics. These work by stopping the growth of bacteria.

This medication is available as a vaginal cream, vaginal suppository, oral capsule, and oral liquid.

This medication is also available in injectable forms to be given directly into a vein (IV) or a muscle (IM) by a healthcare professional.

Common side effects of Klindan include nausea, vomiting, joint pain, heartburn, pain when swallowing, and white patches in the mouth.

Dosage

Take Klindan exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Take the capsule with a full glass of water to keep it from irritating your throat.

Measure the oral liquid with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Klindan is sometimes given as an injection into a muscle, or injected into a vein through an IV. You may be shown how to use injections at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Use a disposable needle only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

To make sure this medicine is not causing harmful effects, you may need frequent medical tests during treatment.

If you need surgery, tell the surgeon ahead of time that you are using Klindan.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Klindan will not treat a viral infection such as the flu or a common cold.

Store at room temperature away from moisture and heat. Protect the injectable medicine from high heat.

Do not store the oral liquid in the refrigerator. Throw away any unused oral liquid after 2 weeks.

Overdose

In the event the patient misses a dose of Klindan, the patient should take it as soon as possible. However, if it is almost time for the next scheduled dose, taking another dose of Klindan may cause an overdose which can lead to serious health complications. In this case, the missed dose should be skipped entirely to avoid an overdose potential. If an overdose of Klindan is suspected the patient should seek immediate medical intervention and assessment. An overdose may involve symptoms such as changes in mood or behaviors, thoughts of self harm, suicidal thoughts, seizures, or convulsions.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Klindan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use Generic Klindan if you are allergic to Generic Klindan components or to to tartrazine.

Be very careful if you're pregnant or you plan to have a baby, or you are a nursing mother.

Try to be very careful with Generic Klindan if it is given to children younger than 10 years old who have diarrhea or an infection of the stomach or bowel. Elderly patient should use Generic Klindan with caution.

Be sure to use Generic Klindan for the full course of treatment.

Avoid alcohol.

It can be dangerous to stop Generic Klindan taking suddenly.

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Neosporosis is a multisystemic disease caused by the intracellular protozoan Neospora caninum. In dogs the disease primarily affects the central nervous system. Canine cutaneous neosporosis is a rare condition often associated with old age or concurrent immunosuppressive treatments for different underlying conditions.

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In the absence of a Bradford sling, I constructed a simple sling to elevate an infected hand from medical equipment that was readily available on the ward. The results were so successful and the experience so comfortable for the patient that the technique should be explained and made clear for other doctors. In this particular case, a serious side effect was avoided namely infection of nearby indwelling metalwork. The patient contacted us afterwards to say how well he felt, he had been looked after and how comfortable the equipment had been to use during his stay in hospital.

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For the treatment of babesiosis, a regimen of atovaquone and azithromycin is as effective as a regimen of clindamycin and quinine and is associated with fewer adverse reactions.

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Eleven patients were colonized or infected with diphtheroids identified as Corynebacterium xerosis. All the patients were compromised hosts by nature of their underlying disease and/or therapy. Two patients developed bacteremia following colonization of the respiratory tract with C. xerosis. Other patients were colonized at various sites, which included the respiratory tract, abdominal and thoracic wounds, amputated limb, and arterial-venous shunt. Distinctive features for the identification of C. xerosis include negative reactions for hemolysis, urease, and motility, and positive reactions for catalase, glucose, sucrose and nitrate reduction. Antimicrobial susceptibility tests were performed by the disk diffusion method. In many instances the organisms were resistant to the antimicrobial regimens received by the patients. This was most frequent for nafcillin, gentamicin, kanamycin, clindamycin, and chloramphenicol. On the other hand, the organisms were highly susceptible to penicillin, ampicillin, cephalothin and carbenicillin.

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Using seven different toxic shock syndrome toxin-1 (TSST-1) producing Staphylococcus aureus strains, we examined the influence on growth and toxin production of subinhibitory concentrations of clindamycin, erythromycin, lincomycin, kanamycin, tetracycline and tunicamycin. The behaviour of six S. aureus (= W/MT-strains) was identical, the one of S. aureus MN8 was different in part. Using the different subinhibitory antibiotic concentrations, bacterial growth was inhibited by tunicamycin only. Toxin production was influenced by clindamycin, erythromycin, lincomycin, kanamycin and tetracycline without simultaneous changes in the number of cells; MN8 was more sensitive to clindamycin and lincomycin than W/MT strains. Very small differences or no differences at all were found between the two bacterial groups in experiments using erythromycin, kanamycin and tetracycline. Tunicamycin caused elevated TSST-1 concentrations of 100% (MN8) or 65% (W/MT) above the control level if used at concentrations of 4 mg/l or 16 mg/l respectively; this result is interpreted as a higher output of TSST-1 caused by the damage to the bacterial cell wall. From these results it is not possible to conclude that different mechanisms of regulation of TSST-1 expression exist between S. aureus MN8 and the other TSST-1 positive S. aureus strains.

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Altogether, 126 erythromycin-resistant strains of S. aureus were detected. Prevalence of cMLSB, iMLSB and MS resistance phenotypes were 92.8%, 6.4%, and 0.8%, respectively; 60.3% of strains had ermA gene and 54.8% ermC gene; 61 strains (48.4%) contained 2 studied erm genes and 42 strains (33.3%) did not have any studied erm genes.

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ADPKD is inherited in an autosomal dominant manner. About 95% of individuals with ADPKD have an affected parent; at least 10% of families can be traced to de novo mutation. Each child of an affected individual has a 50% chance of inheriting the pathogenic variant. If the pathogenic variant has been identified in an affected family member prenatal testing for pregnancies at increased risk may be available from a clinical laboratory that offers either testing of this gene or custom prenatal testing. Preimplantation genetic diagnosis (PGD) may be an option for some families in which the pathogenic variant has been identified and is increasing being employed by families at risk for ADPKD

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Testing of 12 pneumococcal strains with differing resistotypes [including tet(M) positive] showed that tigecycline, amoxicillin-clavulanate, imipenem, and ceftriaxone did not select for resistant clones after 50 sequential subcultures. By comparison, azithromycin, clarithromycin, clindamycin, telithromycin, levofloxacin, moxifloxacin, and gemifloxacin did show resistant clones. Tigecycline also yielded a low frequency of resistance in single-step tests compared to all beta-lactams, macrolides/ketolides, and quinolones tested.

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klindan 600 mg 2015-04-04

This case demonstrated that for this young patient with cellulitis of the knee, timely recognition and referral, together with patient or parent education and immediate treatment, were essential to Klamoks Drug a successful outcome.

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A 34-year-old male suffered from an allergic reaction after inhalation of decontaminating drugs for BMT. Clinical challenge tests were undertaken to determine the causal drug. It was found that vancomycin hydrochloride (VCM) repeatedly induced dyspnea, fever, hypoxia, eosinophilia, and elevation of CRP. Therefore, clindamycin (CLDM) was used instead of VCM for decontamination of patient respiratory tract. Although complete decontamination of the respiratory tract was not achieved during the leukocytopenic period, BMT was successful, Para Que Sirve La Azitromicina Suspension 200 Mg and there were no life-threatening infectious complications. Although inhaled VCM-induced allergic reaction may be a very rare complication in the BMT setting, careful clinical attention should be paid to such patients.

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Collaborative studies documented the reproducibility of broth microdilution susceptibility tests of Streptococcus pneumoniae against nine antimicrobial agents and of disk diffusion tests with six of those drugs. Replicate tests of Streptococcus pneumoniae ATCC 49619 in five Amoclan Dose Medscape different laboratories led to the following provisional quality control limits: cefdinir--0.03 to 0.25 microgram/ml and 26 to 31 mm; cefetamet--0.5 to 2 micrograms/ml and 20 to 25 mm; ciprofloxacin--0.25 to 1 microgram/ml and 20 to 26 mm; clinafloxacin--0.03 to 0.125 microgram/ml and 28 to 34 mm; grepafloxacin--0.06 to 0.5 microgram/ml and 21 to 28 mm; PD131628--0.125 to 0.5 microgram/ml and 24 to 29 mm; clindamycin--0.03 to 0.12 microgram/ml; cefpodoxime--0.03 to 0.12 microgram/ml; and trospectomycin--1 to 4 microgram/ml (disk tests were not evaluate for the latter three drugs).

klindan 600 mg 1 ampul 2017-10-02

Thirty-two macrolide-resistant Streptococcus pyogenes isolates were found Ciprofloxacin 500mg Antibiotics Dosage among 594 clinical isolates collected from 1990 to 1998 in Santiago, Chile, for an overall prevalence of 7.2%. Among the 32 resistant isolates, 28 (87.5%) presented the M phenotype and 4 (12. 5%) presented the MLS(B) phenotype. Serotyping and pulsed-field gel electrophoresis analysis showed genetic diversity among the resistant isolates.

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During 2003, a total of 8 (47%) of 17 infants with bacteremia due to S. aureus had MRSA infection. Isolates from 6 (75%) of these 8 infants carried the SCCmec genes (class B mec and ccr2) that are characteristic of community MRSA; 4 isolates were type IVa. All 6 isolates were resistant to beta-lactam Supreme Assembly Social Order Of The Beauceant antibiotics and erythromycin; 1 was also resistant to clindamycin. One isolate was nontypeable, and another carried the SCCmec type II gene (typical of hospital-associated strains) and was susceptible only to vancomycin. Seven (88%) of 8 infants presented in septic shock. Despite initial treatment with vancomycin, 3 (38%) died, and 3 survivors had complications requiring prolonged antimicrobial therapy; these 6 infants had MRSA isolates with genetic characteristics of isolates of community origin.

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Two groups of 16 patients each with ischaemic foot ulcers were studied. In one group, patients received a mean of 284 (SD 116) mg gentamicin and in the other, 1200 mg clindamycin. The antibiotics were given intravenously, intra-arterially, and by TVA-Bier in a randomised order at intervals of Para Que Sirve Flagenase 400 Pediatrico Suspension 48 hours. Biopsy samples were taken from the edge of the ulcers 20 minutes and 3 hours after TVA-Bier, and 1 hour and 3 hours after intravenous and intra-arterial injection. At the same times blood samples were taken.

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It was demonstrated that none of the excipients contained in the TRI-726 polymer matrix caused any loss in clindamycin?s antimicrobial activity following incorporation into the polymer matrix. Thus, Nidazol 500 Mg Tablet the new patent pending TRI-726 drug delivery matrix was both inert and non-reactive toward the incorporated clindamycin in terms of chemical degradation (< 10% degradation under accelerated conditions over 6 months) and antimicrobial activity.

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Three drugs showed clear signs of precipitation Azithromycin Single Dose Chlamydia when mixed with TPN and these products should not be co-administered in the same infusion line.

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These findings suggest that SCCmec II MRSA and a PVL strain of MRSA are significant pathogens in patients with SSTIs presenting to hospitals in Kenya, and that MRSA cases are prevalent at publicly funded health care facilities.