INCREASINGLY WIDESPREAD USE OF THE NEW FLUOROQUINOLONES: For the treatment of airway infections raises the risk of bacterial resistance, particularly for Streptococcus pneumoniae. IN FRANCE, PRESCRIPTIONS FOR QUINOLONES: Are much less frequent than in several other large countries. This is also true for anti-pneumococcal fluoroquinolones although prescriptions have increased moderately over the last year. FURTHER TO THE CONCERNS RESULTING: From the publication of two studies from Canada and Hong Kong in 1999 that suggested an increasing rate of fluoroquinolone resistant pneumocci, it has been established that the real rate of isolation of resistant strains remains very low, particularly in France, while the rate of penicillin and macrolide resistant strains has been more than 50% in most studies. S. PNEUMONIAE RESISTANCE: Basically results from chromosomal mutations that inhibit the affinity of fluoroquinolones for intrabacterial targets (topoisomerase i.v. and gyrase DNA), or increase active exflux. ALTHOUGH THE CURRENT OUTLOOK IS RATHER OPTIMISTIC: It is nevertheless indispensable to implement preventive measures for prescriptions and personal health care in order to limit the emergence and dissemination of fluoroquinolone-resistant penumococcal strains.
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The activities of telithromycin and levofloxacin against 99 mycoplasma strains were compared to those of several macrolides, ofloxacin, and doxycycline. Telithromycin MICs of =0.25 microgram/ml were found for all isolates, except for Mycoplasma hominis, while levofloxacin was active at concentrations of =1 microgram/ml against all species studied.
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506 patients were identified, representing 517 uSSSI treatment episodes. The mean durations of monotherapy and all antibacterial prescription therapy were significantly shorter for the moxifloxacin than the levofloxacin group (differences of 1.97 days [p = 0.015] and 1.60 days [p = 0.036], respectively). The original prescription duration, treatment failure rate and treatment charges were lower for the moxifloxacin group than the levofloxacin group, but differences were not statistically significant (p = 0.241, 0.395 and 0.199, respectively).
Patients using eyedrops for glaucoma had a lower culture-positive rate of bacteria in the conjunctival sac, probably due to being washed out by the eyedrops. However, Gram-negative bacteria were detected in the eyedrop group. Bacteria isolated from the eyedrop group had lower resistance to levofloxacin, a finding that may have clinical relevance.
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Microcyn Rx is safe and at least as effective as oral levofloxacin for mild diabetic foot infections.
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The activities of garenoxacin, ciprofloxacin, levofloxacin, moxifloxacin, trovafloxacin, amoxicillin-clavulanate, piperacillin-tazobactam, imipenem, clindamycin, and metronidazole against 20 anaerobes were tested. At two times the MIC, garenoxacin was bactericidal against 19 of 20 strains after 48 h and against 17 of 20 after 24 h. Other drugs, except clindamycin (which gave lower killing rates), gave killing rates similar to those for garenoxacin.
Phenprocoumon is the most frequently used vitamin K antagonist in Germany. The aim of this study was to estimate the risk of serious bleeding as a result of the use of drugs with potential interaction with phenprocoumon.
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Prospective multicenter study.
Switch therapy outcomes in hospitalized patients with CAP receiving initial IV therapy with tigecycline are comparable to those of patients receiving initial IV therapy with levofloxacin. These data support the use of IV tigecycline in hospitalized patients with CAP when the switch therapy approach is considered. CLINICALTRIALS.GOV IDENTIFIER: NCT00081575.
Out of the 220 samples analyzed, 181 (82.3%) were infected (P aeruginosa [41.8%]; S aureus [30%]; co-infection of P aeruginosa and S aureus [10.5%]). Wound healing was significantly (P < 0.01) dependent on the presence of P aeruginosa and S aureus in the study population. S aureus and P aeruginosa showed the highest (74.2% and 71.3%, respectively) and lowest (38.2% and 34.8%) susceptibilities to levofloxacin and sparfloxacin, respectively. P aeruginosa was 68.7% susceptible to rifampicin; 53% to erythromycin, 52.2% to vancomycin; 38.3% to ceftriazone; 36.5% to cefuroxin; and 32.2% to oxacillin. S aureus was 51.7% susceptible to rifampicin, 37.1% to cefuroxin; 33.7% to ceftriazone; 28.1% to vancomycin; and 25.8% to oxacillin. Twelve weeks after antibiotic administration, 54% of samples had no growth and showed accelerated wound healing; 26.7% yielded P aeruginosa, while 19.3% yielded S aureus.